Your total trip with all stops is around 130 miles / 210 km, taking roughly 2.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between SLM and Madrid, Spain.
Start from Salamanca-Matacán Airport.
Avila, Spain is stopping point #1 after driving about 90 km (60 miles) or 1 hour.
Finally, Madrid, Spain is your destination after driving about 120 km (70 miles) or 1.5 hours. Your total trip with all stops is around 210 km or 130 miles, taking roughly 2.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.