Open this map directly on Google Maps.
Here is a list of connecting flights from John Wayne Airport to Santa Ana, California. This can help you find a one-stop flight with the shortest layover time. We found a total of 4 flights to Santa Ana, CA with one connection:
Travelmath provides an online direct flight finder to help you determine whether there is a non-stop flight to your destination. Nonstop flights can be faster, since they don't require you to change planes or stop at a connecting airport. However, sometimes you can't find any non-stop flights between two cities. In that case, you may want to search for a direct connection that goes through an airline's hub. You can use the flight search engine on this site to find the best airline routes for your trip. Enter any city or IATA airport code to check for direct flights.