The cost of driving (USD) from Astypalaia Island National Airport to Santorini is:

complicated...   You might even have to swim.   May we suggest you fly instead?

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Astypalaia Island National Airport

IATA: JTY
ICAO: LGPL
City: Astypalaia Island
Country: Greece
Category: airports
Estimated gas price in Greece: $5.01

Santorini

Island: Santorini
Country: Greece
Category: islands
Estimated gas price in Greece: $5.01

Cost of driving

Travelmath provides an online driving cost calculator to help you determine how much you'll spend on gas for your next road trip. You can enter airports, cities, states, countries, or zip codes to compute the cost of driving between locations. Driving distances are calculated using actual driving directions if they are available, or a GPS-accurate method for the straight line distance. Automatic estimates are provided for local gas prices and vehicle fuel efficiency in miles per gallon (mpg) or liters per 100 kilometers (L/100 km), based on the make and model of your car, SUV, or minivan. Don't let the economy and rising oil prices stop you from taking your next trip. You can use this tool to find out if it's cheaper to fly or drive to your destination.