Drag the line on the map to calculate the driving distance for a different route.
The total driving distance from Knoxville, TN to Durham, NC is 338 miles or 544 kilometers.
Your trip begins in Knoxville, Tennessee. It ends in Durham, North Carolina.
If you are planning a road trip, you might also want to calculate the total driving time from Knoxville, TN to Durham, NC so you can see when you'll arrive at your destination.
You can also calculate the cost of driving from Knoxville, TN to Durham, NC based on current local fuel prices and an estimate of your car's best gas mileage.
If you're meeting a friend, you might be interested in finding the city that is halfway between Knoxville, TN and Durham, NC.
Planning to fly a plane instead? You might be more interested in calculating the straight line distance to fly from Knoxville, TN to Durham, NC.