The total driving distance from Buffalo, NY to Durham, NC is 693 miles or 1 115 kilometers.
Your trip begins in Buffalo, New York.
It ends in Durham, North Carolina.
If you are planning a road trip, you might also want to calculate the total driving time from Buffalo, NY to Durham, NC so you can see when you'll arrive at your destination.
You can also calculate the cost of driving from Buffalo, NY to Durham, NC based on current local fuel prices and an estimate of your car's best gas mileage.
Since this is a long drive, you might want to stop halfway and stay overnight in a hotel. You can find the city that is halfway between Buffalo, NY and Durham, NC.
Planning to fly a plane instead? You might be more interested in calculating the straight line distance to fly from Buffalo, NY to Durham, NC.